Journal: Pharmaceutics
Article Title: Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways
doi: 10.3390/pharmaceutics15082063
Figure Lengend Snippet: Photomicrographs of brain sections (cerebral cortex, subiculum, and fascia dentata in hippocampus, striatum, and cerebellum areas) stained by hematoxylin and eosin (magnification 40×). AD; Alzheimer disease, EGCG; Epigallocatechin-3-gallate, VIN; vinpocetine, WG; Wheatgrass, Q10; coenzyme Q10, Vit; vitamin. ( a1 – a5 ): control group, ( b1 – b5 ): AD group, ( c1 – c5 ): AD + cocoa group, ( d1 – d5 ): AD+cocoa+EGCG group, ( e1 – e5 ): AD + cocoa + VIN group, ( f1 – f5 ): AD + cocoa + WG group, ( g1 – g5 ): AD + cocoa + CoQ10 group, ( h1 – h5 ): AD + cocoa + Vit B complex group, and ( i1 – i5 ): AD + cocoa + VitE + VitC + Se group. The blue arrow shows no histopathological modification, the orange arrow displays nuclear pyknosis and degeneration, and the black arrow shows focal eosinophilic plagues, the Scare bar was 25µm.
Article Snippet: Vit B complex, Vit E, and Vit C were obtained from Kahira Pharmaceutical and Chemicals Ind.
Techniques: Staining, Modification